NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS Russian patent published in 2011 - IPC C07F9/12 C07D421/04 C07D215/233 A61K31/4709 A61K31/66 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to derivatives with anticancer activity of formulae:

, , , , ,

R₂', R₃', R₄', R₅' and R₆' are selected from H, Y(CH₂)_nCH₃, X and (CH₂)_nNR₈R₉; Y is selected from O and S; X is selected from F, Cl and Br; R₈ and R₉ are selected from (CH₂)_nCH₃; R₂, R₃, R₄ and R₅ are selected from H, Y(CH₂)_nCH₃, X and (CH₂)_nNR₈R₉, or R₃ and R₄ together form -Y(CH₂)_nY-; R₁ and R₁' are selected from H, Li⁺, Na⁺, K⁺, N⁺R₈R₉R₁₀R₁₁ or benzyl, where R₁₀ and R₁₁ are selected from H, (CH₂)_nYH, (CH₂)_nN(C_nH_2n+1)(C_mH_2m+1) or (CH₂)_nCH₃, where n and m are integers from 0 to 4, q is an integer from 1 to 4.

EFFECT: obtaining novel compounds with anticancer activity.

37 cl, 3 dwg, 10 ex, 2 tbl