DERIVATIVES OF 1,2,3,4-TETRAHYDRONAPHTHALENE, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT Russian patent published in 2002 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of 1,2,3,4-tetra- -hydronaphthalene of the formula (I) as (R)-enantiomers, (S)-enantiomers or racemates in the form of free base or their pharmaceutically acceptable salts or solvates where X means N or CH; Y means , NR₂-CO or CO-NR₂; R₂ means H or -alkyl; R₁ means H or -alkyl; R₃ means phenyl that can be mono- or disubstituted with R₄ where R₄ means H, halogen, CN, CF₃, -alkoxy-group, optionally substituted heterocyclic ring comprising one or two heteroatoms taken among N, O or COR₈; R₈ means heterocyclic ring comprising one or two heteroatoms taken among N, O; R₉ means -alkyl, OCHF₂, OH, halogen atom, -alkoxy-group, - alkoxy-- -alkyl. Compounds of the formula (I) show antagonistic activity with respect to 5-HT_1B receptors and can be used in medicine. EFFECT: improved methods of synthesis and treatment, valuable medicinal properties. 32 cl, 1 dwg, 2 tbl, 87 ex