FIELD: organic chemistry, chemical technology. SUBSTANCE: invention describes a new method for preparing N,N,6-trimethyl-2-(4-methylphenyl)- imidazo-[1,2-a]-pyridine-3-acetamide as a compound eliciting clinical activity as a soporofic agent. Method for preparing involves interaction of ester comprising hydroxy-group of the formula (X) 
with compound prepared in situ from thionyl chloride and dimethylformamide followed by reduction with sulfoxylate- formaldehyde sodium or sodium hydrosulfide and the following amination of prepared ester of the formula (XII) 
in polyhydroxylated solvent medium at temperature 30-70 C. Method provides high yield and quality of the end substance and using available and safety parent compounds. EFFECT: improved preparing method. 5 cl, 6 ex
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