NEW ACYLATED PSEUDODIPEPTIDES, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF Russian patent published in 2004 - IPC

FIELD: organic chemistry, peptides, pharmacy. SUBSTANCE: invention relates to N-acylated pseudodipeptides corresponding to the general formula (I): wherein R₁ and R₂ each means carboxylic acid acyl group comprising from 2 to 24 carbon atoms being each group can be saturated or unsaturated, linear or branched, unsubstituted or comprising one or some substituents taken among hydroxyl, alkyl, groups: alkoxy-, acyloxy-, amino-, acylamino-, acylthio- and C₁-C₂₄- alkylthio-; descriptors m, p and q = from 1 to 10; descriptor n = from 0 to 10; X and Y each means hydrogen atom or acid group taken among the following groups: carboxy-C₁-C₅-alkyl, -CH-[(CH₂)_mCOOH][(CH₂)_nCOOH] wherein m = 0-5; n = 0-5; phosphono-C₁-C₅--alkyl, dihydroxyphosphoryloxy-C₁-C₅-alkyl, dimethoxyphosphoryl, phosphono, hydroxysulfonyl, hydroxysulfonyl-C₁-C₅--alkyl, hydroxysulfonyloxy-C₁-C₅-alkyl in neutral or charged form under condition that at least one of substituents X and Y means above indicated acid form in neutral or charged form; A and B each means independently of one another oxygen, sulfur atom or imino-group -NH; and to their therapeutically acceptable salts, method for their preparing and pharmaceutical composition eliciting immunomodulating properties comprising at least one compound of the general formula (I) as an active component. EFFECT: improved preparing method, valuable medicinal properties of compounds. 19 cl, 23 tbl, 51 dwg