METHOD FOR PREPARING 2-AMINO-4-[HYDROXY(METHYL)-PHOSPINYL]BUTYRIC ACID Russian patent published in 2006 - IPC C07F9/30 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for preparing -amino-4-[hydroxy(methyl)phosphinyl]butyric acid of the formula (I): wherein R* means hydrogen atom or alkyl with 1-4 carbon atoms, or its salts with acid and bases. Method involves the following stages: a) (stage 1) trivalent methylphosphorus compound of the formula (II): wherein R¹ and R² mean independently halogen atom, (C₁-C₁₈)-alkoxy-, benzyloxy- or phenoxy-group that can be substituted, or one radical among R¹ or R² means hydroxy-group is subjected for interaction with unsaturated aldehyde or ketone of the formula (III): wherein R* has the abovementioned value in the presence of carboxylic acid anhydride and if necessary alcohols; b) (stage 2) the reaction mixture obtained at stage 1 is treated with ammonia/ammonium chloride and sodium cyanide, or with a mixture consisting of ammonia and hydrocyanic acid, or with a mixture consisting of ammonia and cyanide, if necessary, in the presence of ammonium chloride, and c) (stage 3) the reaction mixture obtained at stage 2 is hydrolyzed. The proposed method provides enhancing yield of compound of the formula (I) from 50% (by the known method) to 90%.

EFFECT: improved preparing method.

8 cl, 7 ex