FIELD: medicine, chemical-pharmaceutical industry and technology, pharmacy. SUBSTANCE: invention relates to method for preparing an anticonvulsant preparation representing 3-benzylamino- Methylenepyrrolidine-2,4-dione (I). Method for preparing involves acylation of aminoacetic acid esters with malonic acid monoester chloroanhydrides in the presence of chloroform as a solvent. Prepared product is converted to 3-alkoxycarbonylpyrrolidine-2,4-dione in alcohol solvent in the presence of sodium alcoholate as cyclizing agent. Prepared product is decarboxylated by three-fold boiling with acetonitrile in the concentration of product (V) 20-30 g/l in reaction mixture followed by cooling, filtration and acetonitrile distillation off. Prepared pyrrolidine- -2,4-dione is added to reaction with corresponding dimethylformamide dialkylacetal or trialkoxymethane and prepared product is treated with benzylamine at 0-5 C followed by isolation of the end product. Method provides elevating yield of the end product without additional purification stages and to provide higher purity degree of preparation. EFFECT: improved preparing method. 3 cl, 2 ex
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