METHOD OF OBTAINING AZD5363 (OPTIONS) AND NEW INTERMEDIATE COMPOUND APPLICABLE THEREIN Russian patent published in 2018 - IPC C07D487/04 C07D498/10 

Abstract RU 2674027 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to a method for producing AZD5363 or a salt of AZD5363, including: (a) reacting 8-(7H-pyrrole[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.5]decane-2,4-dione: or its salt with (S)-3-amino-3-(4-chlorophenyl)propan-1-ol or its salt in the presence of a base, and (b) isolating AZD5363 or AZD5363 as a salt. Variant of the method of producing AZD5363 or the salt of AZD5363 is also disclosed along with an intermediate compound for carrying out these methods, in particular 8-(7H-pyrrole[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.5]decane-2,4-dione or its salt.

EFFECT: technical result is the development of an improved method of obtaining AZD5363 or its salt, which reduces the duration of the method of production, reduces the level of impurities in the final product, improves the performance of the method and, as a consequence, ensures a high yield of the final product.

7 cl, 3 ex

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RU 2 674 027 C2

Authors

Aavula Sanjeev Kumar

Chandukudlu House Vinod Kumar

Chikkulapalli Anil

Chinnakalai Karthikeyan

Dates

2018-12-04Published

2015-05-26Filed