FIELD: chemistry.
SUBSTANCE: present invention relates to a method for producing AZD5363 or a salt of AZD5363, including: (a) reacting 8-(7H-pyrrole[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.5]decane-2,4-dione: or its salt with (S)-3-amino-3-(4-chlorophenyl)propan-1-ol or its salt in the presence of a base, and (b) isolating AZD5363 or AZD5363 as a salt. Variant of the method of producing AZD5363 or the salt of AZD5363 is also disclosed along with an intermediate compound for carrying out these methods, in particular 8-(7H-pyrrole[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.5]decane-2,4-dione or its salt.
EFFECT: technical result is the development of an improved method of obtaining AZD5363 or its salt, which reduces the duration of the method of production, reduces the level of impurities in the final product, improves the performance of the method and, as a consequence, ensures a high yield of the final product.
7 cl, 3 ex
Title | Year | Author | Number |
---|---|---|---|
PHARMACEUTICAL COMBINATION CONTAINING ALK INHIBITOR AND SHP2 INHIBITOR | 2018 |
|
RU2769132C2 |
PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | 2021 |
|
RU2819004C1 |
SUBSTITUTED N2-(4-AMINO-2-METHOXYPHENYL)-N4-[2-(DIMETHYLPHOSPHORYL)-PHENYL]-5-CHLORO-PYRIMIDINE-2,4-DIAMINES AS MODULATORS OF ALK AND EGFR, APPLICABLE FOR TREATING CANCER | 2015 |
|
RU2607371C1 |
PYRROLOPYRAMIDINES, WITH INHIBITING PROPERTIES TO CATEPSIN K AND METHOD OF OBTAINING THEM (VERSIONS) | 2002 |
|
RU2331644C2 |
AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS | 2015 |
|
RU2683309C2 |
AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS | 2011 |
|
RU2567395C2 |
COMBINATION TREATMENT OF CANCER | 2012 |
|
RU2640485C2 |
CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DESTRUCTION OF ANDROGEN RECEPTORS AND USE THEREOF | 2020 |
|
RU2825000C2 |
PHARMACEUTICAL COMBINATIONS | 2014 |
|
RU2684106C2 |
SUBSTITUTED TRICYCLIC COMPOUNDS | 2020 |
|
RU2827641C1 |
Authors
Dates
2018-12-04—Published
2015-05-26—Filed