FIELD: medicine, pharmaceutical technology, pharmacy. SUBSTANCE: injection solution comprises the following components, wt. - %: phenazepam, 0.05-0.15; polyvinylpyrrolidone, 0.5-1.2; Tween-80, 2.0-10.0; glycerol, 5.0-15.0; sodium pyrosulfite, 0.1-0.3; sodium hydroxide solution, to pH = 6.0-7.5; water, the balance. Method for preparing the injection solution involves mixing phenazepam with Tween-80, stirring the prepared mixture with glycerol at temperature 70-90 C, addition of sodium pyrosulfite, polyvinylpyrrolidone and sodium hydroxide in the amount providing pH = 6.5-7 and water followed by repeated stirring and filtration of the solution. Invention provides the realization of the indicated designation. EFFECT: improved preparing method. 6 cl, 1 ex
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Authors
Dates
2004-02-27—Published
2002-03-12—Filed