FIELD: medicine; medical engineering. SUBSTANCE: device has porous matrix enclosed in perforated impermeable container. Strong prolonged response against the antigen is induceable, or the already existing or potential immune response is inhibitable or blockable as a result of manipulations with biological accessibility of antigen in the inside of device and time period control for antigen to be introduced into the device with respect to time the device is implanted to a mammalian. EFFECT: enhanced effectiveness of therapeutic and preventive vaccination of mammalians not affected earlier by antigen. 57 cl, 33 dwg
