DERIVATIVES OF THIENOPYRANE CARBOXAMIDES Russian patent published in 2004 - IPC

Abstract RU 2225409 C2

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to derivatives of thienopyrane carboxamides of the formula (I): wherein R represents aryl, cycloalkyl or polyhalogenalkyl group; R₁ represents alkyl, alkoxy-, polyfluoroalkoxy-, hydroxy- or trifluoromethanesulfonyloxy-group; each of R₂ and R₃ represents independently hydrogen or halogen atom or alkoxy- or polyfluoroalkoxy-group; n = 0, 1 or 2; or N-oxide or pharmaceutically acceptable salt of such compound. Invention describes also two variants of method for their preparing and pharmaceutical composition based on compounds of the formula (I). Compounds elicit the enhanced selectivity with respect to α₁-adrenergic receptor and low activity with respect to reducing blood pressure. EFFECT: valuable medicinal properties of compounds. 15 cl, 3 tbl, 10 ex

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RU 2 225 409 C2

Authors

Leonardi Amedeo

Motta Dzhanni

Riva Karlo

Testa Rodol'Fo

Dates

2004-03-10—Published

2000-07-28—Filed