FIELD: chemistry.
SUBSTANCE: invention relates to a pan-RAF kinase inhibitor, which is a compound with formula (Ia) or a pharmaceutically acceptable salt thereof, as well as to a pharmaceutical composition based on it. In general formula (Ia), R1 is selected from the group consisting of H, pyridyl, morpholinyl, piperazinyl, 4-methyl-piperazin-1-ylphenyl, oxetan-3-yloxy, 2-morpholinoethoxy, 3-morpholinopropoxy and tetrahydrofuran-3-ylmethoxy; R2 is selected from the group consisting of H, C1-6 hydroxyalkoxy, C1-6 alkoxy-C1-6 alkoxy, tetrahydropyran-4-yloxy, tetrahydrofuran-3-yloxy, oxetan-3-yloxy, tetrahydrofuran-3-ylmethoxy, tetrahydropyran-4-ylmethoxy and oxetan-3-ylmethoxy; R3 is H; where R1, R2 and R3 do not represent H at the same time; R4 is selected from the group consisting of C1-6 haloalkyl and C1-6 cyanoalkyl; R5 is selected from the group consisting of H, C1-6 alkyl and 4-methyl-piperazin-1-ylmethyl.
EFFECT: providing a new selective pan-RAF kinase inhibitor that can be used to treat diseases mediated by RAF and/or RAS kinases.
8 cl, 5 dwg, 7 tbl, 189 ex.
(Ia)
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