FIELD: biochemistry.
SUBSTANCE: described are isolated monoclonal antibodies which specifically bind to PD-1 with high affinity. Also disclosed are nucleic acid molecules coding described antibodies, expression vectors and host cells and methods of pressing said antibodies. Also disclosed are bispecific molecules and pharmaceutical compositions containing described antibodies. Described are methods of detecting PD-1 and treatment of various diseases, including cancer and infectious diseases.
EFFECT: invention widens range of anti-PD-1 antibodies.
35 cl, 54 dwg, 7 tbl, 25 ex
| Title |
Year |
Author |
Number |
| HUMAN MONOCLONAL ANTIBODIES TO THE PROTEIN OF PROGRAMMED DEATH 1 (PD-1) AND METHODS OF TREATING CANCER USING ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTIC AGENTS |
2016 |
- Korman Alan Dzh.
- Srinivasan Mokhan
- Van Chanyuj
- Selbi Mark Dzh.
- Chen Bin
- Kardarelli Zhozefin M.
|
RU2732924C2 |
| HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED DEATH 1 (PD-1) PROTEIN AND CANCER TREATMENT METHOD USING ANTI-PD-1-ANTIBODIES SEPARATELY OR COMBINED WITH OTHER IMMUNOTHERAPEUTIC AGENTS |
2006 |
- Korman Alan Dzh.
- Srinivasan Mokhan
- Van Chanjuj
- Selbi Mark Dzh.
- Chehn' Bin
- Kardarelli Zhozefin M.
|
RU2406760C2 |
| HUMAN MONOCLONAL ANTIBODIES SPECIFIC FOR PROGRAMMED CELL DEATH 1 (PD1) PROTEIN AND METHODS OF TREATING CANCER WITH USING ANTI-PD1 ANTIBODIES EITHER INDIVIDUALLY, OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTIC AGENTS |
2006 |
- Korman Alan Dzh.
- Srinivasan Mokhan
- Van Chanjuj
- Selbi Mark Dzh.
- Chehn' Bin
- Kardarelli Zhozefin M.
- Khuan Khajchun'
|
RU2494107C2 |
| PD-1 ANTIBODIES AND USE THEREOF |
2016 |
|
RU2722451C1 |
| ANTIBODIES DIRECTED TO PROTEIN OF PROGRAMMED DEATH OF CELL-1 (PD-1) |
2014 |
- King Devid Dzh.
- Keri Merilin
|
RU2723050C2 |
| ANTIBODIES BINDING TO PD-1 AND THEIR APPLICATIONS |
2019 |
|
RU2773758C2 |
| PD-1 BINDING ANTIBODIES AND METHODS OF THEIR USE |
2019 |
|
RU2812280C1 |
| NEW MONOCLONAL ANTIBODIES TO PROGRAMMED CELL DEATH 1 (PD-1) PROTEIN |
2016 |
- Zheng, Yong
- Li, Jing
- Gololobov, Gennady
- Zhang, Xinhua
- Yang, Baotian
- Tang, Zhewei
- Li, Dong
- Xu, Jianqing
- Wang, Zhuozhi
|
RU2757316C2 |
| ANTIBODIES AGAINST PD-1 AND THEIR USE |
2018 |
- Yang, Yi
- Xie, Jingshu
- Dong, Chunyan
- Yang, Fang
- Lu, Chengyuan
- Cheng, Xiaodong
- Shen, Yuelei
- Ni, Jian
- Guo, Yanan
- Chen, Yunyun
|
RU2788616C2 |
| ANTI-PD-1 ANTIBODIES |
2015 |
- Zha Jiping
- Sun Ziyong
- Qiu Junzhuan
|
RU2711141C2 |
