DERIVATIVES OF OLEANDOMYCIN CLASS AND METHOD FOR THEIR PREPARING Russian patent published in 2004 - IPC

FIELD: organic chemistry, antibiotics, chemical technology, pharmacy.

SUBSTANCE: invention relates to new compounds of macrolide antibiotic oleandomycin class of the general formula (I):

wherein R¹ represents separately the group -CH₂CH₃, the group of the formula (II)

that represents in common with R² the group of the formula (III)

or in common with R⁴ represents the group of the formula (IV)

or the group of the formula (V)

R² in common with R³ represents ketone, or in common with R¹ represents the group of the formula (III); R³ represents hydroxy-group (OH) separately or in common with R² represents ketone; R⁴ represents methyl group separately or in common with R¹ represents group of the formula (IV) or group of the formula (V); R⁵ represents hydrogen atom separately or benzyloxycarbonyl group; R⁶ represents hydrogen atom, methyl group or benzyloxycarbonyl group separately, and to their pharmaceutically acceptable inorganic or organic acid salts. These compounds are intermediate substances for preparing structural analogues of chimeric oleandomycin with the simplified structure of the left part of its molecule that elicit the powerful antibacterial effect. Invention provides preparing new derivatives of oleandomycin class used in producing antibacterial agents.

EFFECT: improved preparing method, valuable medicinal properties.

12 cl, 12 ex