CRYPTOFICINE COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OF CELL PROLIFERATION AND METHOD OF PATHOLOGICAL STATE RELIEF Russian patent published in 2002 - IPC

FIELD: organic chemistry, medicine, oncology, pharmacy. SUBSTANCE: invention relates to a novel cryptoficine compound of the formula (I) where Ar means methyl or phenyl or any simple unsubstituted or substituted aromatic or heterocyclic group; R₁ means halogen atom; R₂ means OH; or R₁ and R₂ can be joined to form epoxy-ring, aziridine ring; R₁ and R₂ can be joined in common to form a double bond between C₁₈ and C₁₉; R₃ means lower alkyl group; R₄ and R₅ mean H; or R₄ and R₅ can be joined to form a double bond between C₁₃ and C₁₄; R₆ means benzyl, hydroxybenzyl (oxybenzyl), alkoxybenzyl, halogenoxybenzyl, dihalogenoxybenzyl, halogenalkoxy-benzyl or dihalogenalkoxybenzyl group; R₇, R₈, R₉, R₁₀ each means independently H or lower alkyl group; X and Y each means independently O, NH. Compounds can be used for inhibition of proliferation of cells in mammal and for treatment of tumors. Invention describes also pharmaceutical composition based on compounds and methods of using. EFFECT: improved method of treatment, valuable medicinal properties of compounds. 56 cl, 10 tbl, 14 dwg, 22 ex