FIELD: organic chemistry, medicine, oncology, pharmacy.
SUBSTANCE: invention relates to new water-soluble phosphonooxymethyl esters of hindered alcohols and phenols. Invention describes phosphonooxymethyl esters of the formula (I):
wherein R-O- represents a residue of pharmaceutical compound comprising alcohol or phenol with exception of taxol and taxol derivatives; R1 means hydrogen atom or alkaline metal ion, or protonated amine, or protonated amino acid; R2 means hydrogen atom or alkaline metal ion, or protonated amine, or protonated amino acid; n means a whole number 1 or 2; m means a whole number at least 1, and to their pharmaceutically acceptable salts. Also, invention describes intermediate compounds, methods for their preparing, pharmaceutical composition eliciting anesthetic effect, method for anesthesia and method for treatment of tumor diseases. Invention provides preparing water-soluble drugs comprising alcohol and phenol.
EFFECT: improved method for treatment, valuable medicinal and pharmaceutical properties of compounds.
20 cl, 4 dwg, 6 ex
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Authors
Dates
2004-09-10—Published
1999-08-06—Filed