METHOD FOR PREPARING N-SUBSTITUTED ETHYL-(2-DIALKOXYPHOSPHORYL-4-CYANO)-BUTANEIMIDATES Russian patent published in 2004 - IPC

Abstract RU 2236414 C1

FIELD: chemistry of organophosphorus compounds, chemical technology.

SUBSTANCE: invention relates to a novel method for preparing N-substituted phosphorylated imidates bearing cyanoethyl-group in structure. Invention describes a method for preparing N-substituted ethyl-(2-dialkoxyphosphoryl-4-cyano)butaneimidates of the formula: wherein R means (C₃-C₄)-alkyl or isoalkyl; R' means C(O)CH₃, C(O)C₆H₅, Si(CH₃)₃. Method involves interaction of N-substituted ethyl-(2-dialkoxyphosphoryl)ethaneimidates with acrylonitrile in the presence of sodium ethylate as a catalyst in dioxane medium in the mole ratio N-substituted ethyl-(2-dialkoxyphosphoryl)ethaneimidate : acrylonitrile : sodium ethylate = 1:(1.05-1.15):(0.1-0.15), respectively, at temperature 40-60^oC. Invention provides preparing new chemical compounds that are perspective for preparing biologically active compounds used in medicine and agriculture.

EFFECT: improved preparing method.

4 ex

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RU 2 236 414 C1

Authors

Shishkin V.E.

Mednikov E.V.

Anishchenko O.V.

Dates

2004-09-20—Published

2003-04-29—Filed