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2 374 258

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(51)

IPC

C07F9/40(2006-01-01)

(21) (22)

Application

2008118727/04, 2008-05-12

(24)

Start date

2008-05-12

(22)

Actual filing date

2008-05-12

(45)

Published

2009-11-27

(72)

Inventor

Shishkin Veniamin Evgen'EvichMednikov Evgenij ViktorovichAnishchenko Oksana Vital'EvnaPopov Jurij Vasil'EvichShevchenko Marija AleksandrovnaKuchurov Il'Ja Vladimirovich

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Volgogradskij Gosudarstvennyj Tekhnicheskij Universitet

METHOD OF PRODUCING N,N-DIALKYL,N'-ACYL-(ACYLDIALKOXYPHOSPHORYL)ETHANEAMIDINES Russian patent published in 2009 - IPC C07F9/40

Abstract RU 2374258 C1

FIELD: chemistry.

SUBSTANCE: present invention relates to a method of producing N,N-dialkyl, N'-acyl-(acyldialkoxyphosphoryl)ethaneamidines and can be used in synthesis of biologically active compounds. The proposed method of producing N,N-dialkyl, N'-acyl-(acyldialkoxyphosphoryl)-ethaneamidines of formula , where R¹=C₃-C₄-alkyl or isoalkyl; R²=CH₃, C₆H₅; R³=C₃-C₃-alkyl; R⁴=CH₃, C₆H₅; involves reacting C-phosphorylated acetamidines with sodium with subsequent acylation of the obtained sodium derivative with acid halides such as acetyl bromide or chloride and benzoyl chloride, in a dioxane medium at molar ratio sodium: C-phosphorylated acetamidine: acid halide = 1:1:1÷1.1, respectively, and temperature between 20 and 50°C.

EFFECT: design of a new method of producing new N,N-dialkyl, N'-acyl-(acyldialkoxyphosphoryl)ethaneamidines with high output of 80 to 86%.

1 cl, 5 ex

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RU 2 374 258 C1

Authors

Shishkin Veniamin Evgen'Evich

Mednikov Evgenij Viktorovich

Anishchenko Oksana Vital'Evna

Popov Jurij Vasil'Evich

Shevchenko Marija Aleksandrovna

Kuchurov Il'Ja Vladimirovich

Dates

2009-11-27—Published

2008-05-12—Filed