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2 385 870

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IPC

C07F9/40(2006-01-01)

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Application

2009102884/04, 2009-01-29

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Start date

2009-01-29

(22)

Actual filing date

2009-01-29

(45)

Published

2010-04-10

(72)

Inventor

Shishkin Veniamin Evgen'EvichPopov Jurij Vasil'EvichMednikov Evgenij ViktorovichAnishchenko Oksana Vital'EvnaShevchenko Marija AleksandrovnaGurba Evgenija Viktorovna

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Volgogradskij Gosudarstvennyj Tekhnicheskij Universitet

METHOD OF PRODUCING N-SUBSTITUTED (2-DIALKOXYPHOSPHORYL-4-CYANO)BUTANAMIDINES Russian patent published in 2010 - IPC C07F9/40

Abstract RU 2385870 C1

FIELD: chemistry.

SUBSTANCE: present invention relates to a method of producing novel N-substituted (2-dialkoxyphosphory-4-cyano)butanamidines of formula ,

where R=C₃-C₄-alkyl or isoalkyl; R¹=C(O)CH₃ C(O)C₆H₅;

R²=N(C₂H₅)2, N(C₃H₇)₂, , which can serve as starting compounds in production of biologically active substances. The proposed method involves reacting corresponding C-phosphorylated acetamidines with acrylonitrile in the presence of sodium ethylate catalyst in a dioxane medium in molar ratio C-phosphorylated acetamidine: acrylonitrile: sodium ethylate equal to 1:1.05-1.15:0.10-0.20 respectively and temperature of 50-60°C for 2 hours.

EFFECT: wider range of chemical compounds, obtaining novel N-substituted (2-dialkoxyphosphory-4-cyano)butanamidines with high output (over 73%).

1 cl, 5 ex

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RU 2 385 870 C1

Authors

Shishkin Veniamin Evgen'Evich

Popov Jurij Vasil'Evich

Mednikov Evgenij Viktorovich

Anishchenko Oksana Vital'Evna

Shevchenko Marija Aleksandrovna

Gurba Evgenija Viktorovna

Dates

2010-04-10—Published

2009-01-29—Filed