FIELD: pharmacy.
SUBSTANCE: invention relates to a composition as multiple particles with modified release that deliveries an active component by impulse or bimodal manner in its effect. This composition as multiple particles with modified release involves a component with immediate release and a component with modified release. Component with immediate release comprises the first series of particles containing an active component and component with modified release comprises the second series of particles containing an active component covered by envelope for sustained-release. This combination of component with immediate release and component with modified release deliveries an active component by impulse or bimodal manner in its effect. Invention relates also to solid oral medicinal formulation that comprises such composition as multiple particles with modified release. Pattern in blood plasma provided by this composition as multiple particles with modified release is useful in reducing tolerance in patient to an active component and improving keeping the treatment regimen by patient by means diminishing in drug intake frequency.
EFFECT: valuable medicinal and pharmaceutical properties of composition.
36 cl, 8 tbl, 1 dwg, 2 ex
