FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to a pharmaceutical composition for pain management, as well as to application of said composition for making a drug for pain management. The declared composition contains a number of multilayer pills containing a water-soluble core, an antagonist layer containing HCI naltrexone and coating the core, an isolating polymer layer coating the antagonist layer, an agonist layer coating the isolating polymer layer, a delayed-release shell coating the agonist layer, an agent layer regulating osmotic pressure and containing sodium chloride immediately under the agonist layer. The isolating polymer layer contains acrylic-methacrylic ester polymers with quaternary ammonium groups, sodium lauryl sulphate in the amount of 1.6 wt % to 6.3 wt % and talc in the amount of 75 wt % to 125 wt % in relation to acrylic-methacrylic ester polymers with quaternary ammonium groups. The agonist layer contains morphine sulphate and hydroxypropyl cellulose, while sodium lauryl sulphate is found in the multilayer pills only in the isolating polymer layer.
EFFECT: invention provides preparing the pharmaceutical composition wherein the antagonist and agonist are isolated from each other, and the antagonist does not release from the composition due to osmotic pressure.
9 cl, 1 tbl, 23 dwg, 1 ex
