THIENOPYRIMIDINES, METHOD FOR THEIR PREPARING, PHARMACEUTICAL PREPARATION AND METHOD FOR ITS PREPARING Russian patent published in 2004 - IPC

Abstract RU 2238274 C2

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention relates to thienopyrimidines of the formula (I):

wherein R¹ and R² in each case represents independently of one another OH or Hal; X means R⁵, monosubstituted R⁷; R⁵ means cycloalkyl comprising 6 carbon atoms; R⁷ means COOH, COOA; A means alkyl comprising from 1 to 6 carbon atoms; Hal represents F, Cl, Br or J wherein at least one radical among R¹ or R² represents OH, and their pharmaceutically acceptable salts also. Compounds inhibit activity of phosphodiesterase V and can be used in treatment of cardiovascular system disturbances. Invention describes also a method for preparing compounds of the formula (I), pharmaceutical preparation based on these compounds and a method for it preparing.

EFFECT: improved preparing method, valuable medicinal and biochemical properties of compounds.

6 cl, 16 ex

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RU 2 238 274 C2

Authors

Jonas Rokhus

Shelling P'Er

Kluksen Frants-Verner

Khrishtadler Marija

Dates

2004-10-20—Published

2000-06-07—Filed