CONDENSED THIENOPYRIMIDINES INHIBITING ACTIVITY OF PHOSPHODIESTERASE V, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION Russian patent published in 2004 - IPC

FIELD: organic chemistry, biochemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to new condensed thienopyrimidines of the formula (I) and their physiologically acceptable salts acting as inhibitors of activity of phosphodiesterase V (PDE V) that can be used for treatment of cardiovascular system and for treatment and/or therapy of disorder of sexual potency. In compounds of the formula (I) R¹, R² each means independently of one another hydrogen atom, OA or Hal; R¹ and R² in common mean also alkylene with 3-5 carbon atoms, -O-CH₂-CH₂-, -CH₂-O-CH₂-, -O-CH₂-O- or -O-CH₂-CH₂-O-; X means R⁴, R⁵ or R⁶ substituted once with substituent R⁷; R⁴ means linear or branched alkylene with 1-10 carbon atoms; R⁵ means cycloalkyl or cycloalkylalkylene with 5-12 carbon atoms; R⁶ means phenyl or phenylmethyl; R⁷ means COOH or COOA wherein A means alkyl with 1-6 carbon atoms; Hal means fluorine, chlorine, bromine or iodine atom. Invention relates also to method for preparing compounds of the formula (I). Method for preparing involves interaction of compound of the formula (II) wherein X has above indicated values and L means Cl, Br, OH, SCH₃ or reaction esterified OH-group with compound of the formula (III) wherein R¹ and R² have above indicated values followed by if necessary conversion of one residue X in the prepared compound of the formula (I) to another residue X by, for example, hydrolysis of ester group to COOH-group and/or conversion of compound of the formula (I) to one of its physiologically acceptable salts. EFFECT: improved preparing method, valuable medicinal and biochemical properties of compounds. 6 cl, 1 tbl, 14 ex