DERIVATIVES OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHOD FOR TREATMENT OF DISORDERS WITH NEURONS INJURY Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, neurology.

SUBSTANCE: invention relates to new derivatives of nitrogen-containing heterocyclic compounds of the formula:

or their pharmaceutically acceptable salts wherein R¹ represents hydrogen atom (H), COCOR², COOR³ or SO₂R³; R² represents (C₁-C₆)-alkyl, (C₁-C₆)-alkenyl, (C₅-C₇)-cycloalkyl, 2-thienyl, 3-thienyl, phenyl or substituted phenyl; R³ represents phenylalkyl; represents saturated five-membered nitrogen-containing heterocyclic ring with one nitrogen atom or benzo-condensed saturated six-membered nitrogen-containing heterocyclic ring; represents oxazole, oxadiazole or thiazole; A is linked with carbon atom of five-membered heteroaromatic ring; represents COO(CH₂)_mAr wherein R¹ has indicated above values, or represents CONR⁴(CH₂)_mAr or (CH₂)_mO(CH₂)_nAr being R¹ can't represent COCOR² or SO₂R³; R⁴ represents hydrogen atom (H) or (C₁-C₄)-alkyl; Ar represents 2-, 3-, or 4-pyridyl; m = 1-4; n = 0-4. The prepared compounds elicit neurotrophic activity and can be used for treatment and prophylaxis of nervous diseases.

EFFECT: valuable medicinal properties of compounds.

15 cl, 3 tbl, 1 dwg, 27 ex