RETINOID-LIKE COMPOUNDS, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT Russian patent published in 2001 - IPC

FIELD: organic chemistry, vitamins. SUBSTANCE: invention relates to compound of the formula (I): or its nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate where X means -O-CO-, -NH-CO-, -CS-NH-, -CO-O-, -CO-NH-, -COS-, -SCH₂-,CH₂-CH₂-,-C≡C-,-CH₂-NH-,-COCH₂-, -NHCS-, -CH₂S-,-CH₂O-,-OCH₂-,-NHCH₂- or -CR⁵=CR⁶-; R^m and R^k mean independently each of other hydrogen, halogen atom; ; n = 0 or 1; R⁴ means -(CH₂)_t--Y, C_1-6-alkyl; R¹ means -CO₂Z; R² and R³ are independently each of other hydrogen atom or C_1-6-alkyl; R^a and R^b are independently each of other hydrogen atom or C_1-6-alkyl; when n = 1 then R^a and R^b can form in common radical of the formula: ; Y means phenyl optionally substituted with C_1-6-alkyl or halogen atom; Z means hydrogen atom or C_1-6-alkyl; R⁵ and R⁶ are independently each of other hydrogen atom or C_1-6-alkyl and t = 0. Invention relates to also methods of prophylaxis and/or treatment of patients with tumors, arthritis and nonmalignant skin pathology that involve administration of compound of the formula (I) to animals and to pharmaceutical composition containing the compound of the formula (I) with mixture of pharmaceutically acceptable carriers also. EFFECT: valuable medicinal properties of compound and composition. 48 cl, 2 tbl, 4 dwg, 163 ex