BENZOTHIOPYRANOINDAZOLES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT OF PATIENT WITH TUMORS Russian patent published in 2000 - IPC

Abstract RU 2154066 C2

FIELD: organic chemistry, medicine, oncology, pharmacy. SUBSTANCE: invention describes the novel compounds benzothiopyranoindazoles of the general formula (I) where n = 2 or 3; R means hydrogen atom, lower alkyl, C(O)H, C(O)R₃, SO₂R₃ and C(O)OR₃; R₁ and R₂ each means independently hydrogen atom or lower alkyl; R₃ means lower alkyl and R₉ means hydrogen atom, lower alkyl, lower alkoxyl or hydroxyl, or their any pharmaceutically acceptable acid addition salt or solvate. Compounds show antitumor activity. Invention describes also pharmaceutical compositions containing benzothiopyranoindazoles and methods of treatment of mammals with tumors and cancer using these compounds. EFFECT: enhanced antitumor activity of compounds. 13 cl, 17 ex

Similar patents RU2154066C2

Title	Year	Author	Number
INDASOLES, BENZISOXAZOLES AND BENZISOTIAZOLES, METHOD OF THEIR OBTAINING, PHARMACEUTICAL COMPOSITIONS AND APPLICATION AS ESTROGENIC MEDICATIONS	2005	Rondo Benua Lafaj Zhan Bonne Pol' Klerk T'Erri Djuk Igor Djuranti Ehrik Puksio Fransua Shilds Zhaklin Blo Kristian Mejllo Filipp	RU2402536C2
BENZIMIDAZOLE DERIVATIVES	2020	Begli, Skott Uillyam Kazimiro-Garsiya, Agustin Chen, Syayun Davoren, Dzhennifer Elizabet Denni, Radzhiakh Oldrin Gerstenberger, Brajan Stefen Lavering, Frenk Eldridzh Parikkh, Mikhir Dineshkumar Strobak, Dzhozef Uolter Trukhillo, Dzhon Isidro	RU2803284C1
P38 INHIBITORS AND APPLICATION METHODS	2004	Manson Mark Mareska Dejvid A. Kim Joungbu Grounberg Robert Ritstsi Dzhejms Rodriges Marta Kim Gangkhikok Vajgers Gaj Rao Chang Balachari Devan Kharvi Darren	RU2357957C2
2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOL-6-(2H)-ONES, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION, AND METHOD OF TREATING TUMOR	1993	A.Pol Krapcho Ehrnesto Menta Ambrodzhio Oliva Sil'Vano Spinelli	RU2130937C1
LYOPHILIZED COMPOSITION CONTAINING THIOXANTENONE AS ANTITUMOR ACTIVE PRINCIPLE AND METHOD OF TREATMENT INVOLVING THIS COMPOSITION	1996	Braun Stefan Sandu Gardial Singkh	RU2157189C2
HETEROCYCLIC MUSCARINIC AGONISTS AND COMPOSITIONS, THEIR USING AND METHODS FOR TREATMENT	2002	Sk'Erbek Nil'S Kokh Kristian Norup Friberg Bo Lennart Mikaehl' Tol'F Bo-Ragnar	RU2292346C2
SUBSTITUTED TETRAHYDROPYRANSPIROPYRROLIDINONE AND TETRAHYDROPYRANSPIROPIPERIDINONE, BASED ON THEM PHARMACEUTICAL COMPOSITION AND APPLICATION FOR THERAPEUTIC PURPOSES	2009	Gao Chzhunli Khartung Rajan Stefani Dehvid	RU2519778C2
HETEROCYCLIC INHIBITORS OF MCT4	2017	Parnell, Kenneth, Mark Mccall, John, M. Romero, Donna	RU2771875C2
PYRROLOPYRIMIDINE COMPOUNDS FOR MALIGNANT TUMOUR TREATMENT	2012	Wang Xiaodong Liu Jing Zhang Weihe Frye Stephen Kireev Dmitri	RU2631655C2
HEXACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND THEIR USING AS ANTITUMOR AGENTS, METHOD FOR PREPARING HEXACYCLIC COMPOUNDS	2002	Murata Takesi Niizuma Satosi Simma Nobuo Suda Khitomi Tsukazaki Masao	RU2299212C2

RU 2 154 066 C2

Authors

Ventland Mark P.

Perni Robert B.

Dates

2000-08-10—Published

1996-02-20—Filed