SUBSTITUTED BENZYLOXYCARBONYLGUANIDINES, METHOD OF THEIR SYNTHESIS AND AGENT INHIBITING Na/H-EXCHANGE Russian patent published in 2002 - IPC

FIELD: organic chemistry, chemical technology, medicine. SUBSTANCE: invention relates to substituted benzyloxy-carbonylguanidines of the general formula (I) where R(1), R(2) and R(3) mean independently each of other hydrogen atom, (C₁-C₈)-alkyl, F, Cl, Br, J, OR(25), R(31) SO₁- where R(25) means pyridyl, quinolinyl, isoquinolinyl; "I" = 2, R(31) means -(C₁-C₈)-alkyl; R(1), R(2) and R(3) mean independently each of other +OR(67) or NR(67)R(68) where R(67) and R(68) mean independently each of other alkyl with 1, 2, 3 or 4 C-atoms; R(4) and R(5) mean independently each of other hydrogen atom, F, Cl; R(6) and R(7) mean independently each of other hydrogen atom; X means oxygen atom or NR(72) where R(72) means hydrogen atom or alkyl with 1, 2, 3 or 4 C-atoms. Invention describes a method of their synthesis. Compounds are effective inhibitors of sodium-proton antiport (Na⁺/H⁺-exchange) and useful as antiarrhythmic agents. EFFECT: improved method of synthesis, valuable medicinal properties. 6 cl, 1 tbl, 31 ex