DERIVATIVES OF IMIDAZOLE WITH BIPHENYLSULFONYL SUBSTITUTION AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of imidazole of the formula (I): wherein symbols have the following values: R₁ means -C_aH_2a-phenyl wherein phenyl moiety is not substituted; a = 0; R₂ and R₃ mean independently of one another F, Cl, Br, J, CO-R(6) or O-R(7); R(6) means hydrogen atom; R(7) means alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; R₄ means S(O)_p-R(16); p = 2; R(16) means alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, and to their physiologically acceptable salts also. Also, invention relates to pharmaceutical composition used for inhibition of cellular Na⁺-dependent bicarbonate/chloride exchange based on these compounds. Invention provides preparing new compounds and pharmaceutical composition based on thereof for aims therapy and/or prophylaxis of diseases wherein the primary or secondary cause is the cell proliferation.

EFFECT: valuable medicinal properties of compounds.

10 cl, 2 ex