FIELD: biotechnology, virology, veterinary science.
SUBSTANCE: the parent virus for preparing the strain A(Georgia)1999/№1721 is isolated in 1999 year from sick cows in private sector of village Ude in Adigensky district, Georgia Republic. The industrial strain A(Georgia)1999/№1721 is prepared by successive passages in sensitive hetero- and homological cell cultures. The strain is deposited in collection of microorganisms VGNKI at registration number A(Georgia)1999/№1721. Virus of the strain A(Georgia)1999/№1721-DEP is reproduced in sensitive cell cultures with accumulation up to 6.0-8.0 lg TCD50/ml for 18-24 h of incubation. At mass infection virus induces cytopathogenic effect (CPE) in 4 h and retains the parent indices in passage in cell cultures for 10 passages. The strain A(Georgia)1999/№1721-DEP elicits high biological, antigenic and immunogenic activity and can be used for preparing agents for specific prophylaxis and diagnosis of foot and mouth disease virus type A that shows homological properties with epizootic virus distributing in Transcaucasian and Near East countries.
EFFECT: valuable properties of strain.
7 tbl, 3 dwg, 5 ex
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