FOOT AND MOUTH VIRUS DISEASE TYPE A STRAIN N 1707 "ARMENIA-98" USED FOR PREPARING DIAGNOSTIC AND VACCINE PREPARATIONS Russian patent published in 1999 - IPC

Abstract RU 2140452 C1

FIELD: virology, veterinary science. SUBSTANCE: industrial strain N 1707 "Armenia-98" is obtained by multiple successive passages on sensitive hetero- and homologous cell cultures. The strain is deposited in Collection of microorganisms VGNKI at N 1707 "Armenia-98-DEP". The strain N 1707 "Armenia-98" is distinguished from both industrial and early isolated epizootic strains of foot and mouth virus disease type A. Virus of the strain N 1707 "Armenia-98" is reproduced in sensitive cell cultures and its accumulation for 20-24 h of incubation is up to 7.0-8.0 lg TTC50/ml. The strain induces TSPD in 4 h after massive infection, retains the parent indices at passage in cell cultures for 10 passages. New industrial foot and mouth virus disease type A strain shows high biological, antigenic and immunogenic activity and can be used for preparing agents for specific prophylaxis and diagnosis of foot and mouth virus disease type A showing homology to epizootic virus in Transcaucasis and Near East countries. EFFECT: new strain of virus indicated above, improved properties and activity. 2 dwg, 8 tbl, 5 ex

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RU 2 140 452 C1

Authors

Zakharov V.M.(Ru)

Spirin V.K.(Ru)

Gritsenko A.I.(Ru)

Maslova N.S.(Ru)

Gusev A.A.(Ru)

Mikhalishin D.V.(Ru)

Koshetsjan T.F.(Ru)

Drygin V.V.(Ru)

Shcherbakov A.V.(Ru)

Kruglikov B.A.(Ru)

Nersesjan Slava Ervandovich

Dates

1999-10-27Published

1999-03-15Filed