SUBSTITUTED PYRIMIDINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, OR N-OXIDES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 1998 - IPC

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: products: substituted pyrimidines of the formula (I) where R¹,R²,R³ and R⁴ - H, C₁-C₆-alkyl, C₁-C₆-perfluoroalkyl; R⁵ - H or if n = 1 then R⁵ together with R³ forms double bond; n = 0-1; p = 0-2; m = 0-3; Ar¹ and Ar² - substituted phenylene, pyridine. Reagent 1: pyrimidine of the formula (II) where R¹,R²,R³,R⁴,R⁵, n and p have values indicated above; Z¹ - split off group; R⁷ - lower alkyl. Reagent 2: amine of the formula H₂N-(CH₂)_m-Ar¹-Ar² where m, Ar¹ and Ar² have above indicated values. Reaction conditions: in the presence of inorganic or organic base. Synthesized compounds are used in medicine as antagonists of angiotensin-II. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 13 cl, 1 tbl