METHOD FOR PREPARATION OF X-RAY AMORPHOUS CARVEDILOL MODIFICATION Russian patent published in 2009 - IPC C07D209/88 

FIELD: chemistry.

SUBSTANCE: invention refers to the methods for preparation of X-ray amorphous carvedilol [(+)-1-(9H-carbazole-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amine}propane-2-ol] modification and can be used in pharmaceutical industry. Method involves the evaporation of carvedilol parent drug in vacuum device at temperature 80-200^oC, residual pressure 5 - 5×10^-4 Torr in a inert gas flow fed with the rate from 10 to 100 ml/min with following condensation at -196 - +25^oC. The process results in obtaining of powder of X-ray amorphous carvedilol [(±)-1-(9H-carbazole-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amine}propane-2-ol] modification with particle size less than 5 mcm.

EFFECT: enhancing of bioactivity.

7 ex, 8 dwg