FIELD: organic chemistry, chemical technology, medicine, oncology, pharmacy.
SUBSTANCE: invention relates to new derivative of taxane of the formula (I):
that elicits strong antitumor effect. Also, invention relates to intermediates substances, a method for preparing compound of the formula (I), a method for preparing 1,14-β-hydroxy-1,14-carbonate-baccatin III-derivatives substituted with isoserine residue at position 3 and to pharmaceutical composition based on compounds of the formula (I). Invention provides preparing new derivative of taxane that elicits higher activity and reduced toxicity as compared with paclitaxel.
EFFECT: improved preparing method, enhanced and valuable medicinal properties of compound.
10 cl, 7 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING TAXANE DERIVATIVES | 2001 |
|
RU2275365C2 |
| METHOD OF PRODUCING TAXANE DERIVATIVES | 2007 |
|
RU2434014C2 |
| C-2'-METHYLATED DERIVATIVES OF PACLITAXEL FOR USING AS ANTITUMOR AGENTS | 2002 |
|
RU2287528C2 |
| METHOD FOR PREPARING 14-BETA-HYDROXYBACCATIN III-1,14-CARBONATE | 2002 |
|
RU2285000C2 |
| SEMI-SYNTHETIC TAXANES AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF | 2001 |
|
RU2259363C2 |
| METHOD FOR PREPARING 14-BETA-HYDROXYBACCATIN III-1,14-CARBONATE | 2002 |
|
RU2291866C2 |
| DERIVATIVES OF 10-DEACETYLBACCATIN-III AND 10-DEACETYL-14β- HYDROXYBACCATIN-III, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION | 1996 |
|
RU2152936C1 |
| 10-DIACETYL-14-BETA-HYDROXYBACCATIN III DERIVATIVES, METHOD OF PREPARING THEREOF, AND COMPOSITIONS COMPRISING SAID COMPOUNDS | 1996 |
|
RU2161615C2 |
| DERIVATIVES OF TAXANE FUNCTIONED BY POSITION 14 AND METHOD FOR THEIR PREPARING | 2003 |
|
RU2320652C2 |
| METHOD FOR PREPARING DERIVATIVES OF BACCATIN III | 2001 |
|
RU2264394C2 |
