METHOD OF PRODUCING TAXANE DERIVATIVES Russian patent published in 2011 - IPC C07D493/08 C07D305/14

Abstract RU 2434014 C2

FIELD: chemistry.

SUBSTANCE: invention relates to an improved method for synthesis of 13-(N-Boc-β-isobutylserinyl)-14β-hydroxybaccatin III-1,14-carbonate (I) , in which carbonylation of 1,14-hydroxy groups of the baccatin backbone is carried out using bis(trichloromethyl carbonate) and the 7-hydroxy group is protected by a trichloroacetyl group. The invention also relates to novel intermediate compounds of formula VII and VIII.

EFFECT: simple process.

3 cl, 6 ex

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RU 2 434 014 C2

Authors

Gabetta Bruno

Siseri Daniele

Dates

2011-11-20—Published

2007-04-25—Filed