FIELD: organic chemistry, chemical technology, medicine.
SUBSTANCE: invention relates to a method for preparing 1-amino-3,5-dimethyladamantane hydrochloride (the preparation memantin or acatinol) used in medicinal practice as agent for treatment of such diseases as Parkinson's disease, neurodegenerative disorders, glaucoma. Method for preparing 1-amino-3,5-dimethyladamantane hydrochloride involves addition of nitric acid to preliminary prepared 1,3-dimethyladamantane emulsion in acetic acid at 10-30oC followed by addition of 30-55% urea solution in water in the mole ratio 1,3-dimethyladamantane : acetic acid : nitric acid : urea = (1:3)-(4:9)-(12:2.5)-5.0, respectively followed by neutralization of obtained reaction mass with alkali an aqueous solution, extraction and the following isolation of product as hydrochloride and its crystallization from water. Method provides preparing product of the high quality that satisfies requirements of Pharmacopoeia.
EFFECT: improved preparing method, enhanced quality of product.
5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF OBTAINING HYDROCHLORIDES OF ADAMANTANE AMINES | 2013 |
|
RU2541545C2 |
| METHOD FOR PREPARING 3,5-DIMETHYLADAMANTYL-1-AMINE OR ITS SALTS | 2005 |
|
RU2309940C2 |
| METHOD OF PRODUCING HYDROCHLORIDES OF AMINE-DERIVATIVES OF ADAMANTANE | 2010 |
|
RU2440971C1 |
| METHOD OF PRODUCING 1-FORMAMIDO-3,5-DIMETHYLADAMANTANE | 2007 |
|
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| METHOD OF OBTAINING 1-ACETAMIDO-3,5-DIMETHYLADAMANTANE | 2014 |
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RU2574077C1 |
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|
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|
RU2464257C1 |
| METHOD OF PRODUCING MEMANTINE AND INTERMEDIATE PRODUCT | 2009 |
|
RU2478611C2 |
| METHOD OF PREPARING ARYLTRIFLUOROETHYLAMINES OR THEIR SALTS OR THEIR OPTICAL ISOMERS OR MIXTURES OF THEIR OPTICAL ISOMERS | 0 |
|
SU725561A3 |
| METHOD OF PRODUCING THIAZOLE DERIVATIVES OR THEIR ACID-ADDITIVE SALTS | 0 |
|
SU1597102A3 |
