METHOD OF OBTAINING HYDROCHLORIDES OF ADAMANTANE AMINES Russian patent published in 2015 - IPC C07C209/16 C07C211/38 C07C209/02 

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining hydrochlorides of adamantane amines, including 1-aminoadamantane hydrochlorides or 3,5-dimethyl-1-aminoadamantane, which are pharmaceutical substance of medications "Midantan" and "AcatinpolMemantine". Method consists in oxidation of cage hydrocarbon, selected from adamantane or methyl-substituted adamantanes, with fuming nitric acid in molar ratio 1:7-13.3 respectively, in presence of glacial acetic acid in molar ratio 1:1-3.25 counted per initial substrate at room temperature. After that, acetone cyanohydrin is added in molar ratio 1:3.5-10.4 and water in molar ratio 1:75.1-102.9 counted per initial substrate, with further heating with boiling of reaction mass for 1-3 h, neutralisation of obtained reaction mass and addition of hydrochloric acid.

EFFECT: method in accordance with invention is simpler in comparison with previously known methods, because it does not require application of hard-to-obtain reagents, eliminates stage of thermal decomposition of intermediate product, makes it possible to increase environmental friendliness, reduce amount of wastewater and is more fire- and explosion-safe.

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