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2 574 077

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IPC

C07C233/06(2006-01-01)

C07C231/08(2006-01-01)

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Application

2014136299/04, 2014-09-05

(24)

Start date

2014-09-05

(22)

Actual filing date

2014-09-05

(45)

Published

2016-02-10

(72)

Inventor

Dzhemilev Usein MemetovichKhusnutdinov Ravil IsmagilovichShchadneva Nina AlekseevnaKhisamova Lilija FagimovnaKislitsina Ksenija Sergeevna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Neftekhimii I Kataliza Rossijskoj Akademii Nauk

METHOD OF OBTAINING 1-ACETAMIDO-3,5-DIMETHYLADAMANTANE Russian patent published in 2016 - IPC C07C233/06 C07C231/08

Abstract RU 2574077 C1

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining 1-acetamido-3,5-dimethyladamantane, which is applied in synthesis of a series of difficult to obtain derivatives of 1,3-dimethyladamantane, for example 1-amino-3,5-dimethyladamantane - active substance of medication "memantine", unique pharmaceutical preparation, effective for treatment of Parkinson's disease, degenerative brain diseases, glaucoma, as well as other CNS disorders at early stages. Method is realised by interaction of 1-bromo-3,5-dimethyladamantane with acetamide in presence of manganese-containing catalysts, selected from the group MnCl₂, MnBr₂, Mn(OAc)₂, Mn(acac)₃, Mn₂(CO)₁₀. Interaction is carried out at temperature 120-130°C for 3-4 hours with molar ratio [1-bromo-3,5-dimethyladamantane]:[acetamide]:[catalyst]= 100:150÷200:1÷3.

EFFECT: simplification of technology of obtaining 1-acetamido-3,5-dimethyladamantane with low catalyst consumption.

1 tbl, 1 ex

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RU 2 574 077 C1

Authors

Dzhemilev Usein Memetovich

Khusnutdinov Ravil Ismagilovich

Shchadneva Nina Alekseevna

Khisamova Lilija Fagimovna

Kislitsina Ksenija Sergeevna

Dates

2016-02-10—Published

2014-09-05—Filed