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2 464 257

(13)

(51)

IPC

C07C233/06(2006-01-01)

C07C231/06(2006-01-01)

(21) (22)

Application

2011116892/04, 2011-04-27

(24)

Start date

2011-04-27

(22)

Actual filing date

2011-04-27

(45)

Published

2012-10-20

(72)

Inventor

Dzhemilev Usein MemetovichKhusnutdinov Ravil IsmagilovichShchadneva Nina AlekseevnaKislitsina Ksenija Sergeevna

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Neftekhimii I Kataliza Ran

METHOD OF PRODUCING 1-ACETAMIDO-3,5-DIMETHYLADAMANTANE Russian patent published in 2012 - IPC C07C233/06 C07C231/06

Abstract RU 2464257 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a novel method of producing 1-acetamido-3,5-dimethyladamantane (1) which can be used in synthesis of the medication memantine. The disclosed method involves reaction of 1,3-dimethyladamantane with acetonitrile in bromotrichloromethane in the presence of water under the action of a Mo(CO)₆ catalyst with molar ratio [1,3-dimethyladamantane]:[CH₃CN]:[CBrCl₃]:[Mo(CO)₆]:[H₂O]=100:100-150:100-150:1-3:1000-2000, at temperature 140-150°C for 5-6 hours. .

EFFECT: easy implementation of the method and absence of by-products.

1 cl, 8 ex, 1 tbl

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RU 2 464 257 C1

Authors

Dzhemilev Usein Memetovich

Khusnutdinov Ravil Ismagilovich

Shchadneva Nina Alekseevna

Kislitsina Ksenija Sergeevna

Dates

2012-10-20—Published

2011-04-27—Filed