DERIVATIVES OF CARBAMIC ACID ESTERS, THEIR PREPARING (VARIANTS) AND THEIR APPLYING AS LIGANDS OF METABOTROPIC GLUTAMATE RECEPTORS Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, pharmacology.

SUBSTANCE: invention relates to new derivatives of carbamic acid esters of the general formula (I):

and their pharmaceutically acceptable salts eliciting activity with respect to metabotropic glutamate receptors mGlu of group I that can be used for treatment of acute and/or chronic neurological disorders. In the general formula (I) R¹ means hydrogen atom or (C₁-C₇)-alkyl; R² and R^2' mean independently of one another hydrogen atom, (C₁-C₇)-alkyl, (C₁-C₇)-alkoxy-group, halogen atom or trifluoromethyl; X means oxygen (O), sulfur (S) atom or two hydrogen atoms not forming a bridge; A¹/A² mean independently of one another phenyl or 6-membered heterocycle comprising 1 or 2 nitrogen atom; B represents group of the formula:

wherein R³ means (C₁-C₇)-alkyl and others; Y means -O-, -S- or a bond; Z means -O- or -S-; or B means 5-membered heterocyclic group of formulae: (a) , (b) , (c) or (d) . Also, invention relates to methods for preparing compounds and to a medicinal agent based on thereof.

EFFECT: improved preparing methods, valuable medicinal properties of compounds.

22 cl, 1 tbl, 2 sch, 78 ex