FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to the compound 1-cyclopropyl-7-([S,S]-2,8-diazabicyclo[4.3.0]none-8-yl)-6- -fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid of the formula (I) 
showing characteristic peak at 168,1 m. d. in 13C-NMP-spectrum and the line at angle 2θ = 26.7 in roentgen diffractogram and exhibiting an antibacterial activity. Preferable form of the compound is its monohydrate crystallizing as prisms that gives the excellent properties of fluidity and friability to nonhydrate form of this compound. EFFECT: valuable antibacterial activity of compound. 4 cl, 8 dwg, 5 tbl, 8 ex
| Title |
Year |
Author |
Number |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S)-2,8-DIAZABICYCLO- [4.3.0]-NONANE-8-YL)-6- FL UORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID WITH CRYSTALLINE MODIFICATION A AND DRUG ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
1999 |
- Khimmler Tomas
- Khalenbakh Verner
- Rast Khubert
|
RU2247122C2 |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6- FLU ORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID OF CRYSTALLINE MODIFICATION B AND MEDICINAL AGENT BASED ON THEREOF ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
1999 |
- Khimmler Tomas
- Khallenbakh Verner
- Rast Khubert
|
RU2248355C2 |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6- FLU ORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID OF CRYSTALLINE MODIFICATION D AND MEDICINAL AGENT ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
2000 |
- Khimmler Tomas
- Rast Khubert
|
RU2248357C2 |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6- FLU ORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID OF CRYSTALLINE MODIFICATION C AND MEDICINAL AGENT ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
2000 |
- Rast Khubert
- Khimmler Tomas
|
RU2248356C2 |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID SEMIHYDROCHLORIDE |
1999 |
- Khimmler Tomas
- Rast Khubert
|
RU2242475C2 |
| TRIHYDRATE OF 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYLCO-[4,3,0]NONAN-8-YL)-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACID |
2005 |
- Rast Khubert
- Kheep Iris
- Grunenberg Al'Fons
- Khallenbakh Verner
- Bennet-Bukhkhol'Ts Khordi
|
RU2383543C2 |
| THERMODYNAMICALLY STABLE CRYSTALLINE (R)-(-)-2- N-[4-(1,1- DIOXIDO-3-OXO-2,3- DIHYDROBENZISOTHIAZOL-2- YL)BUTYL]AMINOMETHYL-CHROMAN HYDROCHLORIDE |
1996 |
- Grunenberg Al'Fons
- Brem Oliver
- Konrad Mikhaehl'
- Zajdel' Ditrikh
|
RU2181723C2 |
| NOVEL CRYSTALLINE FORMS OF SODIUM SALT OF (4-{4-[5-(6-TRIFLUOROMETHYL-PYRIDIN-3-YLAMINO)PYRIDIN-2-YL]PHENYL}CYCLOHEXYL) ACETIC ACID |
2011 |
|
RU2612556C2 |
| INDAZOLE DERIVATIVE SALTS AND THEIR CRYSTALS |
2017 |
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RU2747399C2 |
| QUINOLONE-AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES IN ADMIXTURE WITH ISOMERS OR INDIVIDUAL ISOMERS, HYDRATES AND SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION |
1993 |
- Uve Peterzen[De]
- Andreas Krebs[De]
- Tomas Shenke[De]
- Tomas Filipps[De]
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- Klaus-Diter Bremm[De]
- Rajner Ehndermann[De]
- Karl-Georg Mettsger[De]
- Ingo Khaller[De]
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RU2105770C1 |
