METHOD FOR PRODUCTION OF PYRLINDONE HYDROCHLORIDE Russian patent published in 2005 - IPC

Abstract RU 2249592 C2

FIELD: organic chemistry.

SUBSTANCE: invention relates to improved synthesis method of pyrlindone hydrochloride having formula (I) 1. Method features intramolecular cyclization of 6-methyl-1-(2-chloroethyl-imino)-1,2,3,4-tetrahydrocarbazole hydrochloride of formula IV 2 at 80°-140°C with alkali agent in presence of phase transfer catalyst to provide 1,2,5,6-tetrahydro-8-methyl-pyrazine[3,2,1-j,k]-4H-carbazole of formula VI 3 followed by reduction at 80°-120°C. Method of present invention makes in possible to produce compound of formula I with yield nearly 70 % and purity more than 99 %.

EFFECT: method of high yield with reduced amount of alkali agent and phase transfer catalyst.

7 cl, 2 ex

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RU 2 249 592 C2

Authors

Ferrari Massimo

Getstsi Marchello

Belotti Paolo

Dzinetti Fabritsio

Dates

2005-04-10Published

2000-04-14Filed