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2 249 599

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IPC

(21) (22)

Application

2003112701/04, 2001-10-02

(24)

Start date

2001-10-02

(22)

Actual filing date

2001-10-02

(45)

Published

2005-04-10

(72)

Inventor

Bes NatashaBikfal'Vi AndreaDeleri Zherar

(73)

Holder

Kommissariat A L'Ehnerzhi AtomikJuniversite Viktor Segalan BordoJuniversite Bordo

CYCLOPEPTIDES, METHOD FOR PRODUCTION THEREOF AND USES AS ANGIOGENESIS INHIBITORS OR ACTIVATORS Russian patent published in 2005 - IPC

Abstract RU 2249599 C2

FIELD: biochemistry.

SUBSTANCE: method relates to new cyclopeptides of general formula cyclo(R₁-Arg-Ile-Lys-Pro-His-R₂) selected from group containing: P11: cyclo(DPhe-Pro-Gln-Ile-Met-Arg-Ile-Lys-Pro-His-Gln-Gly-Gln-His-Ile-Gly-Glu) (SEQ ID NO:5), P16: cyclo(Arg-Ile-Lys-Pro-His-Gln-Gly (SEQ ID NO:8), P17: cyclo(Pro-Arg-Ile-Lys-Pro-His-Gln-Gly) (SEQ ID NO:9), P19: cyclo(Gln-Ile-Met-Arg-Ile-Lys-Pro-His-Gln-Gly-Gln-His-Ile-Gly-Glu) (SEQ ID NO:10), P20: cyclo(Dphe-Pro-Gln-Ile-Met-Arg-Ile-Lys-Pro-His-Gln-Gly-Gln-His-Ile-Gly) (SEQ ID NO:11), P23: cyclo(DPhe-Pro-Arg-Ile-Lys-Pro-His-Gln) (SEQ ID NO:13), P24: cyclo(Gly-Arg-Ile-Lys-Pro-His) (SEQ ID NO:25), as well as P11, P20 and P23 with DPhe substituted by DTyr. Cyclopeptides are useful in systems for angiogenesis inhibition. System includes substrate with cyclopeptides attached by organic spacer arm optionally containing group cleavable by any fermentation system.

EFFECT: angiogenesis inhibiting cyclopeptides.

23 cl, 4 dwg, 2 tbl, 2 ex

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RU 2 249 599 C2

Authors

Bes Natasha

Bikfal'Vi Andrea

Deleri Zherar

Dates

2005-04-10—Published

2001-10-02—Filed