FIELD: biotechnology.
SUBSTANCE: present invention relates to the field of biotechnology, specifically to non-naturally occurring cysteine knot peptides (CKP), and can be used in medicine. The invention makes it possible to obtain new peptides capable of efficient VEGF-A binding and inhibiting. Peptides in accordance with the present invention contain a cysteine knot and are capable of forming an intramolecular scaffold that enhances the overall protein stability.
EFFECT: invention can be applied in medical practice for treatment of ocular diseases characterized by abnormal angiogenesis and abnormal vascular permeability.
58 cl, 48 tbl, 3 ex, 16 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| STABLE AND SOLUBLE ANTIBODIES INHIBITING VEGF | 2019 |
|
RU2747735C2 |
| ELEMENTS THAT BIND TO IL-1 BETA | 2013 |
|
RU2711118C2 |
| VARIANT CD3 BINDING DOMAINS AND THEIR USE IN COMBINATION THERAPY FOR TREATMENT OF DISEASES | 2019 |
|
RU2810222C2 |
| STRUCTURES HAVING SIRP-ALPHA DOMAIN OR ITS VERSION | 2016 |
|
RU2740672C2 |
| ANTIBODIES AGAINST HtrA1 AND METHODS OF THEIR APPLICATION | 2016 |
|
RU2750285C2 |
| NOVEL OXYNTOMODULIN DERIVATIVES AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM FOR TREATING OBESITY | 2012 |
|
RU2739209C2 |
| ANTIBODIES AGAINST SIGNAL-REGULATORY ALPHA PROTEIN AND THEIR APPLICATION METHODS | 2017 |
|
RU2771964C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING INSULIN AND GLUCAGON | 2019 |
|
RU2823246C2 |
| DOG ANTIBODIES WITH MODIFIED CH-CH SEQUENCES | 2014 |
|
RU2815059C2 |
| ADAM9-BINDING MOLECULES AND THEIR APPLICATION METHODS | 2017 |
|
RU2783619C2 |
