FIELD: organic synthesis.
SUBSTANCE: invention provides methods for preparing lamellarine compounds of general formula II: 
(II) via intramolecular cyclization of compounds having general formula I: 
(I), in which formulas moiety RA1RA2C-CRA3RA4 forms optionally monosubstituted aryl group or optionally monosubstituted aromatic 3-6-membered heteromonocyclic group with one nitrogen atom; Y represents hydrogen atom, optionally monosubstituted C1-C20-alkyl, optionally monosubstituted C2-C20-alkenyl, optionally monosubstituted C2-C20-alkynyl, hydroxy, optionally monosubstituted amino, optionally monosubstituted C1-C20-alkoxy, optionally monosubstituted C1-C20-alkenoxy, optionally monosubstituted C1-C20-alkynoxy, optionally monosubstituted aryl, optionally monosubstituted saturated or unsaturated 3-6-membered heteromonocyclic group with one nitrogen atom, carboxy, carboxyester, carboxamide, C1-C20-acyl, C1-C20-acyloxy, mercapto, optionally monosubstituted C1-C20-alkylthio, halogen, nitro, sulfate, phosphate, or cyano; W and X, together with nitrogen and carbon atoms to which they are linked, form group selected from quinoline, isoquinoline, dehydroquinoline, and pyridyl groups all optionally monosubstituted, dihydro- or tetrahydro-derivatives of indicated groups, and optionally monosubstituted phenantridine; wherein optional substituent is selected from C1-C20-alkyl, C2-C20-alkenyl, C2-C20-alkynyl, aryl, halogen, halo-C1-C20-alkyl, halo-C2-C20-alkenyl, halo-C2-C20-alkynyl, haloaryl, hydroxy, C1-C20-alkoxy, C2-C20-alkenyloxy, aryloxy, benzyloxy, halo-C1-C20-alkoxy, halo-C1-C20-alkenyloxy, haloaryloxy, nitro, nitro-C1-C20-alkyl, nitro-C2-C20-alkenyl, nitro-C2-C20-alkynyl, nitroaryl, nitro-substituted 3-6-membered heteromonocyclic group with one nitrogen atom, amino, C1-C20-alkylamino, di-C1-C20-alkylamino, C2-C20-alkenylamino, C2-C20-alkynylamino, arylamino, diarylamino, benzylamino, dibenzylamino, C1-C20-acyl, C2-C20-alkenylacyl, C2-C20-alkynylacyl, arylamino, diarylamino, benzylamino, dibenzylamino, C1-C20-acyl, C2-C20-alkenylacyl, C2-C20-alkynylacyl, arylacyl, C1-C20-acylamino, di-C1-C20-acylamino, C1-C20-acyloxy, C1-C20-alkylsulfonyloxy, arylsulfenyloxy, 3-6-membered heteromonocyclic group with one nitrogen atom, oxy-, amino-, and halogen-derivatives of the latter, C1-C20-alkylsulfenyl, arylsulfenyl, carbo-C1-C20-alkyloxy, carbo-C6-C24-aryloxy, mercapto, C1-C20-alkylthio, benzylthio, C1-C20-acylthio, cyano, sulfate, and phosphate; V represents halogen, hydrogen, or oxygen atom; and intermediates having general formulas Ia and Ib:
EFFECT: expanded synthetic possibilities in lamellarine series.
28 cl, 1 dwg, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METAL COMPLEXES FOR USE IN ATOM OR GROUP TRANSFER AND OLEFIN EXCHANGE REACTIONS | 2005 |
|
RU2394039C2 |
| NEW INHIBITOR BASED ON A QUINOLINE DERIVATIVE | 2019 |
|
RU2802283C2 |
| DEAZAPURINES AND USE THEREOF | 2003 |
|
RU2380368C2 |
| ANTIVIRAL COMPOUDS | 2006 |
|
RU2441869C2 |
| COMPOUNDS AS INHIBITORS OF VLA-4 | 2000 |
|
RU2264386C2 |
| NUCLEOSIDE ARYL PHOSPHORAMIDATES AND USE THEREOF AS ANTI-VIRAL AGENTS FOR TREATING HEPATITUS C VIRUS | 2007 |
|
RU2464272C2 |
| PYRIDO [2,3-d] PYRIMIDINES, USEFUL AS HCV INHIBITORS AND SYNTHESIS METHODS THEREOF | 2006 |
|
RU2444522C2 |
| COMBINATIONS WHICH INCLUDE RECEPTOR S1P AGONIST AND JAK3 KINASE INHIBITOR | 2005 |
|
RU2415678C2 |
| HIV-INHIBITING 5-(HYDROXYMETHYLENE- AND AMINOMETHYLENE)SUBSTITUTED PYRIMIDINES | 2007 |
|
RU2452737C2 |
| 6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDROPYRIDO (3,2-b) INDOLE-2-ONES EFFECTIVE AS ANTIINFECTIOUS PHARMACEUTICAL AGENTS | 2005 |
|
RU2377243C2 |
