6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDROPYRIDO (3,2-b) INDOLE-2-ONES EFFECTIVE AS ANTIINFECTIOUS PHARMACEUTICAL AGENTS Russian patent published in 2009 - IPC C07D471/04 C07D519/00 A61K31/475 A61K31/4741 A61P31/18 

FIELD: pharmacology.

SUBSTANCE: present invention refers to compounds of formula (I) , to its N-oxides, salts, stereoisomer forms where n is equal 1, 2 or 3; R¹ means cyano group; X means bivalent radical NR² or O; R² means hydrogen or C_1-10alkyl, each Q¹ independently stands for direct coupling, -CH₂- or -CH₂-CH₂-; each R⁴ independently means hydrogen or C_1-4alkyl; each R^5a, R^5b, R^5c independently means hydrogen, C_1-4alkyl or arylC_1-4alkyl; each R^5e, R^5f independently means hydrogen, C_1-4alkyl or arylC_1-4alkyl, or R^5e and R^5f together can form bivalent alkandiyl radical of formula -CH₂-CH₂- or -CH₂-CH₂-CH₂-; R¹¹ means aryl, arylC_1-4alkyl, C_1-4alkylcarbonyl, arylcarbonyl, arylC_1-4alkylcarbonyl, C_1-4alkyloxycarbonyl, arylC_1-4alkyloxycarbonyl, R^5aR^5bN-carbonyl, hydroxyC_1-4alkyl, C_1-4alkyloxyC_1-4alkyl, arylC_1-4alkyloxyC_1-4alkyl, aryloxyC_1-4alkyl, pyridyl; -a¹=a²-a³=a⁴- means a bivalent radical of formula -CH=CH-CH=CH- (c-1); where one or two hydrogen atoms in (c-1) are substituted by radical C_1-6alkyl, C_1-4alkoxy, halogen, hydroxy group, (R^5g)(R^5h)N-(C_1-4alkandiyl)-O-trifluoromethyl, cyano group, radical -COOR⁴, (R^5a)(R^5b)N-sulphonyl, pyrrolidinyl-sulphonyl, piperidinyl sulphonyl, radical N(R^5a)(R^5b), radical (a-1), (a-7), morpholinyl, (R^5g)(R^5h)N-(C_1-4alkandiyl)-N(R^5c)-, C_1-6alkylcarbonylamino, C_1-6alkyloxycarbonylamino, C_1-6alkylsulphonylamino, (R^5a)(R^5b)N-C_1-4alkyl; R²⁰ means hydrogen, spiro (C₂-₄alkylenedioxy), spiro (diC_1-4alkyoxy) or -NR^5gR^5h; each R^5g or R^5h independently means either hydrogen, or C_1-4alkyl, or R^5g and R^5h together with nitrogen atom whereto attached form pyrrolidinyl, piperidinyl or morpholinyl; R³ means nitro group, cyano group, amino group, halogen, hydroxy group or C_1-4alkoxy; aryl means phenyl optionally substituted with one or more substitutes chosen from the group consisting of C_1-6alkyl, C_1-4alkoxy, halogen, hydroxy, amino and trifluoromethyl. Besides it relates to the pharmaceutical composition with antiviral activity, and method for making said compounds.

EFFECT: there are prepared and described new compounds with antiviral activity.

9 cl, 15 ex, 2 tbl