NUCLEOSIDE ARYL PHOSPHORAMIDATES AND USE THEREOF AS ANTI-VIRAL AGENTS FOR TREATING HEPATITUS C VIRUS Russian patent published in 2012 - IPC C07H19/20 A61K31/7076 A61K31/708 A61K31/12 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula I with antiviral activity, which can be used in medicine , where Ar is naphthyl; T is selected from H-, F-, N₃-, -NH₂, -OH, C_1-3-alkyl, C_1-3alkyl-O-, -SH and C_1-3alkylthio; V is selected from -OT', -H, -F and -Cl; where T is selected from -H, -CH₃, C_1-16alkylcarbonyl, C_2-18alkenylcarbonyl, C_1-10alkoxycarbonyl, C_3-6cycloalkylcarbonyl and C_3-6cycloalkyloxycarbonyl; T" is selected from -H, -CH₃, C_1-16alkylcarbonyl, C_2-18alkenylcarbonyl, C_1-10alkyloxycarbonyl, C_3-6cycloalkylcarbonyl and C_3-6cycloalkyloxycarbonyl; n equals 0 or 1, and, when n=1, X=0, when n=0, a double bond exists between position 3 and 4 and X is selected from H, OH, F, Cl, Br, I, C_1-6alkyl and NR₅R₆; R₅ and R₆ are selected from H and C_1-6alkyl; Z is selected from H, OH, F, Cl, Br, I, C_1-6alkyl and NR₅R₆; Y is selected from H, OH, F, Cl, Br, I, C_1-6alkyl, C_2-8alkynyl, NR₅R₆; Q is selected from O, S and CR₇R₈; R₇ and R₈ are selected from H and C_1-6alkyl; R₁ and R₂ are selected from H, C_1-20alkyl, C_2-20alkenyl, C_1-20alkoxyC_6-30alkyl, C_1-20alkoxyC_6-30aryl, C_2-20alkynyl, C_6-30aryl, C_3-20cycloalkylC_6-30aryl and C_5-20heterocyclyl; R₃ and R₄ are selected from H, C_1-20alkyl, C_2-20alkenyl, C_1-30alkyl, C_1-20alkoxyC_6-30aryl, C_2-20alkynyl, C_6-30aryl, C_3-20cycloalkylC_6-30aryl and C_5-20heterocyclyl; R₁ and R₄ can together contain a -(CH₂)₃-alkylene chain.

EFFECT: novel biologically active compounds are disclosed.

27 cl, 9 ex, 2 tbl