PYRIDO [2,3-d] PYRIMIDINES, USEFUL AS HCV INHIBITORS AND SYNTHESIS METHODS THEREOF Russian patent published in 2012 - IPC C07D471/04 A61K31/519 A61P31/14 

FIELD: chemistry.

SUBSTANCE: invention relates to novel pyrido[2,3-d]pyrimidines of formula (V) and use of compounds of formula (I), containing a compound of formula (V), to prepare a medicinal agent used for inhibiting HCV replication in mammals infected with HCV, as well as a pharmaceutical composition based on said compounds. In formula (I)

R¹ denotes hydrogen, amino, mono- or disubstituted amino, where amino group substitute(s) can be selected from C_1-6alkyl, C_1-4alkyloxyC_1-4alkyl, diC_1-4alkylaminoC_1-4alkyl/piperidin-1-ylC_1-4alkyl, phenylC_1-4alkyl, where the phenyl group can further be substituted with C_1-4alkoxy; L denotes -NR⁸-; R² denotes Het², where said Het² denotes an aromatic monocyclic 6-member heterocycle which contains one nitrogen atom and is optionally substituted with one or more substitutes selected from C_1-4alkyl; polyhalogenC_1-4alkyl, halogen, -COOR⁷, -CONR^4aR^4b, -OR⁷, -SR⁵, and where C_1-4alkyl can further be substituted with -COOR⁷; R³ denotes phenyl which is optionally substituted with one or two halogen atoms; each of R^4a and R^4b independently denotes hydrogen, C_1-4alkyl, hydroxyC_1-4alkyl; each R⁵ independently denotes C_1-4alkyl; each R⁷ independently denotes hydrogen or C_1-4alkyl; and each R⁸ independently denotes hydrogen or C_1-10alkoxycarbonyl. The values of radicals in formula (V) are given in the claim.

EFFECT: improved method.

18 cl, 4 dwg, 1 tbl, 2 ex