FIELD: biotechnology, veterinary science.
SUBSTANCE: he present innovation deals with manufacturing biopreparations for oral immunization in animals. One should grow vaccinia rabic virus, TC-80 strain in a certain passage cell culture to mix it with protective components (peptone, lactose, pectin). Mixing should be carried out at 14 : 5 : 1 ratio (viral suspension : stabilizing medium, consisting of 40% peptone solution with 8% lactose solution : 4% pectin solution, correspondingly), a semifinished product obtained after mixing should be applied onto a bait (a porous briquette) to be frozen and freeze dried for 24-30 h. The method includes decreased number of stages for manufacturing necessary vaccine being more efficient and economical. The vaccine keeps immunogenic properties for 5 d, not less at environmental temperature being up to 20 C and during storage period for 6 mo at 6-8 C.
EFFECT: higher efficiency of manufacturing.
2 ex, 1 tbl
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Authors
Dates
2005-04-27—Published
2003-07-10—Filed