AMINOCYCLOHEXANOL ETHERS, COMPOSITION HAVING ANTIARRHYTHMIC ACTIVITY AND USES THEREOF Russian patent published in 2005 - IPC

FIELD: pharmaceutical chemistry, medicine.

SUBSTANCE: invention relates to new compounds of formula I ,

solvates or pharmaceutically acceptable salts having antiarrhythmic activity, including ventrical fibrillation, as well as pharmaceutical compositions containing the same. Compounds of present invention are useful in treatment or prevention of arrhythmia, modulation of ion channel activity, for topic or local anesthesia, etc. In formula I X is direct bond, -C(R₆,R₁₄)-Y- and C(R₁₃)=CH-; Y is direct bond, O, S, and C1-C4-alkylene; R₁₃ is hydrogen, C₁-C₆-alkyl, C₃-C₈-cycloalkyl, unsubstituted aryl or benzyl; R₁ and R₂ are independently C₃-C₈-alkoxyalkyl, C₁-C₈-hydroxyalkyl and C₇-C₁₂-aralkyl; or R₁ and R₂ together with nitrogen atom directly attached thereto form ring of formula II ,

wherein said ring is formed by nitrogen and 3-9 ring atoms selected independently from carbon, sulfur, nitrogen and oxygen, etc; R₃ and R₄ are independently attached to cyclohexane ring in 3-, 4-, 5-, or 6-position and represent independently hydrogen, hydroxyl, C₁-C₆-alkyl and C₁-C₆-alkoxy; and when R₃ and R₄ are bound with the same atom of cyclohexane ring they may form together 5- or 6-membered spiroheterocycle ring containing one or two heteroatoms selected from oxygen and sulfur; A is C₅-C₁₂-alkyl, C₃-C₁₃-carbocyclic ring, or ring structure as defined herein.

EFFECT: new antiarrhythmic drugs.

30 cl, 12 dwg, 34 ex