CHALCONES AND PHARMACEUTICAL COMPOSITIONS BASED ON THE SAME Russian patent published in 2005 - IPC

FIELD: pharmaceutical industry, in particular new bioactive chalcones.

SUBSTANCE: invention relates to new chalcones of formula I

, pharmaceutically acceptable salts or solvates thereof, wherein Ar is optionally substituted C₅-C₁₀-carbocycle group or 5- or 6-membered heterocycle group having sulfur atom in cycle, and Ar substituents are selected independently from Cl, Br, F, CN, SCH₃ and OR¹⁰, wherein R¹⁰ is linear or branched C₁-C₆-hydrocarbon; R is OH or R¹⁰; R² and R³ are independently phenyl, saturated linear or branched C₁-C₆-hydrocarbon, or R² and R³ together with carbon atom attached thereto form 5- or 6-membered carbocycle group with the proviso, that in compounds where R is OH and both R² and R³ are methyl, Ar is not phenyl, 4-chlorophenyl, 4-chlorophenyl, 4-methylphenyl, 2-chlorophenyl, 3,4-dimethoxyphenyl, or 4-methoxyphenyl. Also disclosed are drug component for treatment or prophylaxis of neoplasm and pharmaceutical compositions with antiproliferation effect based on compounds of formula I.

EFFECT: new chalcone derivatives with value bioactive action.

26 cl, 2 tbl, 22 ex