FIELD: organic chemistry, pharmaceutical industry.
SUBSTANCE: invention relates to clathrate of azithromycin hydrate with 1,2-propyleneglycol of formula I 
, wherein m =1-2 and n = 0.20-0.40. Method for production of target compound includes azithromycin dissolution in acetone followed by addition of 1,2-propyleneglycol and water in solution, formed crystal filtering, washing with water and drying. Also disclosed is pharmaceutical composition for microbial infection treatment based on clathrate of formula I.
EFFECT: azithromycin with reduced hygroscopicity and increased storage stability.
7 cl, 7 dwg, 2 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CRYSTALLINE AZITHROMYCIN L-MALATE MONOHYDRATE AND PHARMACEUTICAL COMPOSITION INCLUDING IT | 2006 |
|
RU2348644C1 |
| AZITHROMYCIN ETHANOLATE, PROCESS FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF | 1999 |
|
RU2240124C2 |
| STABLE PERORAL SUSPENSION OF NON-DIHYDRATED AZYTROMICINA | 2004 |
|
RU2325149C2 |
| METHODS FOR AZITROMICINE WET GRANULATION | 2002 |
|
RU2283651C2 |
| DRY GRANULATED AZITHROMICINE COMPOSITIONS | 2003 |
|
RU2283092C2 |
| HYDRATES OF ERYTHROMYCIN SALTS, THEIR OBTAINING AND APPLICATION | 2009 |
|
RU2510659C2 |
| DIRECT PRESSABLE AZITHROMICINE-CONTAINING FORMULATIONS | 2002 |
|
RU2277914C2 |
| AZITHROMYCIN MONOHYDRATE AND METHOD FOR ITS PREPARING | 2001 |
|
RU2279439C2 |
| METHOD OF AZITHROMYCIN DIHYDROCHLORIDE PREPARING | 1995 |
|
RU2134271C1 |
| CRYSTALLINE FORMS OF 6-(1H-IMIDAZOL-1-YL)-2-PHENYLQUINAZOLINE AND ITS SALTS | 2010 |
|
RU2557547C2 |
